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These findings enable the rational design of therapeutic strategies which it is hoped will profoundly modify the progression of these diseases.
γ-Secretase inhibitors (GSIs) are being investigated for their potential to modify the progression of Alzheimer disease based on their ability to regulate amyloid-β (Aβ) accumulation.
This study was aimed at improving the activities of the reference compounds, donepezil and AP2238, and at broadening the range of activities of new derivatives as, due to the multifactorial nature of AD, molecules that modulate the activity of a single protein target are unable to significantly modify the progression of the disease.
These results indicate that FKN may be able to modify the progression of renal damage in MRL/lpr mice.
Strategies to improve the response to therapy are needed to modify the progression of HCV related liver diseases.
Treatment remains only symptomatic as unfortunately there are currently no therapies that modify the progression of the disease (2).
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The goal of proper mould filing cannot be achieved without proper gating design which influences the flow pattern, further affects the temperature distribution and modifies the progression of solidification.
Further prospective studies in this cohort will be done to evaluate whether HAART has any role in modifying the progression of cervical dysplasia in these HIV-seropositive women.
NSAIDs are considered an important pharmacologic class of agents that act as modulators of the host response, modifying the progression of periodontal disease, as evidenced by animal studies [ 10, 11, 15].
Clearly, these agents have been embraced as a therapy for relapsing-remitting MS and in a cost conscious clinical environment concerned with limited health care dollars their impact should be examined not only in clinical terms such as reducing relapse rates, or severity or modifying the progression of the disease, but also with an understanding of their economic consequences.
As a result, it is possible that structural or function modifications in the MSH4 Ala97Thr/ MLH3 Leu844Pro interaction might be associated with an increased risk for breast cancer, modifying the progression of MMR pathway and therefore increasing the mitotic recombination rates in mammary gland cells.
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