Sentence examples for modify the phenotype from inspiring English sources

A careful literature search confirmed that for most of the mammalian orthologs of these modifiers there exists experimental evidence that they modify the phenotype of several ND models in mammalian cells (see Table  3 and Additional file 1 for details about the orthologs).

AHI1 seems to act as a modifier of CEP290[ 133] and NPHP1[ 134], and PDZD7 can modify the phenotype in Usher syndrome patients who have a homozygous USH2A mutation [ 135].

Gene transfer is a therapeutic strategy which uses genetic information, usually in the form of DNA, to modify the phenotype of cells.

These results collectively indicate that microenvironmental factors can uniquely modify the phenotype of differentiated recruited monocytes inducing marked changes in mRNA levels and also in miRNA expression and kinetics that may modulate the remarkable flexibility of monocyte responses to specific environmental cues.

However, the range of phenotypes observed in humans, from complete agenesis to hypoplasia, along with the expression of Lrp4 mRNA in multiple cell types of the kidney throughout the embryonic period suggest this molecule may have additional roles in kidney development, or that other factors exist, which can modify the phenotype.

Does Nf1 hemizygosity modify the phenotype?

iRhom homozygosity did not modify the phenotypes of indicated mutations (Mao and Freeman, 2009; Freeman and Bienz, 2001).

So although it is possible that passenger genes near the mutations of interest modify the phenotypes studied here, reasonable practical measures were taken to minimize passenger regions surrounding the mutations.

It is possible that the manifestation of the most severe phenotype is due to an unlikely combination of genetic and non-genetic factors (endogenous or environmental factors, which may be precipitating or modifying the phenotype).

Rescue experiments are inadequate here, because even a modest increase in AR expression modifies the phenotype of the prostate tumor cells [6].

In a deficiency screen for dominant modifiers 13 out of 109 assayed deficiencies (covering around a 55% of the genome), visibly modified the phenotype being most of them dominant suppressors (Table S2).