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Multi-target approaches are necessary to properly analyze or modify the function of a biochemical pathway or a protein family.
The currently approved therapies for Alzheimer's disease (AD) in the US are designed to modify the function of specific neurotransmitter systems in the brain.
Tissue engineering is an emerging new area in life sciences that targets the development of biological substitutes to modify the function of a tissue to repair and maintain its properties.
Cleavage of OPN by PC5/6 may modify the function of OPN in bone and/or modulate other enzymatic cleavages of OPN, leading to alterations in the bone phenotype.
The CO binding kinetic studies show that the GST-α-Hb/rβ-Hb complex and recombinant Hb A exhibit the same allosteric behavior as for native Hb A. The GST moiety, which does not modify the function of the complex, can be easily eliminated by cleavage by the PreScission Protease.
Regenerative medicine is a new biomedicine discipline that takes advantage of the recent advancements in the fields of stem cell biology, molecular biology, and tissue engineering to derive tissue substitutes, in an attempt to replace or modify the function of diseased organs.
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"The Government of Wales Act is clear that the assembly cannot legislate to modify the functions of a minister of the crown without their consent, unless such a modification is consequential or incidental to other provisions in the Bill".
CTGF and transforming growth factor-beta (TGFβ-1) have been shown to modify the functions of each other.
Calpains are another family of proteolytic enzymes containing ubiquitous and tissue-specific isoforms of Ca2+-activated cysteine proteases which can modify the functions of proteins by cleaving at a limited number of specific sites [40].
The location of this LD block suggests that these variations somehow modify the functioning of FGFR2.
This fits a scheme in which calpains do not degrade target proteins, but modify the functions of targets.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
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CEO of Professional Science Editing for Scientists @ prosciediting.com