Furthermore, alterations of miR-levels have been implicated in the de-regulation of critical players in major cellular pathways, modifying the differentiation, proliferation and survival of tumor cells.
Mechanistically we hypothesized that an increase in specific locally produced cytokines during recovery from injury were modifying the differentiation of glial progenitors towards astrocytes at the expense of the more developmentally-appropriate oligodendrocytes.
The data from these studies also suggest that THOC5 may be a useful tool for studying stem cell biology, for modifying the differentiation processes and for cancer therapy.
Growth factors such as FGF-2 (or bFGF) and TGF-ß have a long tradition in tissue engineering for modifying the differentiation potential of MSCs.
In fact, Nouri-Shirazi and Guinet (2003), and Nouri-Shirazi et al. (2007) reported that nicotine influences the immune system by modifying the differentiation of dendritic cells (DCs) into atypical DCs.
Our results showed that a reduction of CXCR4 expression/function does not modify the spontaneous differentiation of leukemic cells, while it impairs the monocytic differentiation of these cells triggered by chemical inducers, particularly by TPA.
However, the present study has provided important evidence that in vitro HA supplementation can significantly modify the chondrogenic differentiation induced by the PAMPS and PDMAAm gels in a complex manner, depending on the concentration.
However, the present study has provided important evidence that in vitro hyaluronic acid supplementation can significantly modify the chondrogenic differentiation induced by the PAMPS/PDMAAm DN gel, depending on the concentration.
We modified the hepatogenic differentiation protocol from previous reports [ 54] by extending the last step of maturation from 2 weeks to 4 weeks in culture medium supplemented with 2% DMSO.
I modify the traditional model of product differentiation proposed by Mussa and Rosen [Mussa, M., Rosen, S., 1978. Monopoly and product quality.
