Four horses died in the previous two editions of the race, prompting organizers to modify the course.
So the Alzheimer's field is poised at an agonizing point — ready to move forward with new methods of diagnosis and drugs that might modify the course of the disease, but without proof that blocking amyloid actually makes a difference.
Despite the wealth of encouraging data from numerous compounds that demonstrate "neuroprotection" in pre-clinical studies of Parkinson's disease, and despite numerous clinical trials, to date, no intervention has been demonstrated to able to modify the course of disease progression.
All this evidence has supported the view that the severity and manifestation of intestinal disease in CF is dependent on the influence of modifier genes, that is to say on the existence of other genes that can modify the course of the disease independently of the type of mutation affecting the CFTR gene17,18,19,20.
Prognostic factor research is important as it helps in refining diagnosis, taking clinical and therapeutic decisions, enhances the design and analysis of intervention trials and helps to identify targets for new interventions that aim to modify the course of a disease.
The understanding of how comorbidities can modify the course and outcome in this population can be of clinical utility both in the diagnostic and treatment field.
Thus, early recognition of patients with CHC at high risk for developing liver fibrosis and cirrhosis is important, because it ensures optimal preventive management strategies that can modify the course of CHC disease [11].
Rather than developing therapies that modify symptoms or the consequences of inherited diseases, a systematic search for resilience factors will change the focus in ways that prevent or modify the course of diseases.
