Sentence examples for modify the binding affinity. from inspiring English sources

Our results identified 10 SNPs, which putatively modify the binding affinity of 24 TFs previously identified as related to TB and HIV/AIDS expression profiles (e.g. KLF5, CEBPA and NFKB1 for TB; FOXP2, BRCA1, CEBPB, CREB1, EBF1 and ZNF354C for HIV/AIDS; and RUNX2, HIF1A, JUN/AP-1, NR4A2, EGR1 for both diseases).

However, some tyrosine substitutions, although involving these two highly conserved positions, did not significantly modify the binding affinity to CXCR4 or capacity to enter Gfox cells.

Conceivably, polymorphisms in the 3′UTR of Cox-2 may modify the binding affinity of regulatory factors and influence its stability and expression.

Evidence is surmounting that DNA methylation can modify the binding affinity of transcription factors to DNA to fine-tune gene expression regulation.

Fj is able to phosphorylate both Ft and Ds (Ishikawa et al., 2008) and modify the binding affinities between the two proteins in vitro (Brittle et al., 2010; Simon et al., 2010); however, the functional in vivo result of these modifications is unknown.

A study reported that the -66 polymorphism modifies the binding affinity for the SP1/SP3 transcription factors.

This polymorphism modifies the binding affinity of the transcriptional factor MZF1, having greater affinity by the A allele.

We hypothesized that CpG methylation status is able to influence the expression of FABP3 by modifying the binding affinity of the region for specific transcription factors.

Mutations in the D-loop regulatory region might alter the rate of DNA replication by modifying the binding affinity of significant trans-activating factors.

These SNPs have wide range of frequency (∼0.001 0.48) in the population and could influence the rate of gene expression by modifying the binding affinity of transcription factors.

Three GPCR accessory proteins called receptor activity-modifying proteins (RAMPs) modify the ligand binding affinity of the receptor such that the CLR/RAMP1 heterodimer preferably binds CGRP, while CLR/RAMP2 and CLR/RAMP3 have a stronger affinity for AM.