Sentence examples for modify the backbone of from inspiring English sources

The aptamer selection procedure was designed to modify the backbone of single-stranded DNA aptamers, where 5′ of both A and C are phosphorothioates, since this provides enhanced nuclease resistance as well as higher affinity than that of a phosphate counterpart.

Here, we first modified the backbone of Scl2 with glycosaminoglycan-binding peptides and cross-linked the modified Scl2 into hydrogels via matrix metalloproteinase 7 (MMP7 -cleavable or non-cleavable scraMMP7 -cleavable

This finding is consistent with previous reports showing that TauCl modifies the backbone of IκB through amino acid oxidation of IκB, thus allowing IκB to become resistant to degradation [ 39, 40].

METHODS AND RESULTS: Soutschek and colleagues made siRNA that would silence the gene for a cholesterol-boosting protein, apolipoprotein B. Using established techniques, they modified the chemical backbone of siRNA to make it more stable.

Leist and colleagues [ 13] first demonstrated that, by modifying the protein backbone of EPO (to produce carbamylated EPO (CEPO)), one is able to retain the tissue-protective effects of EPO.

Models that estimate land-use impacts on biodiversity at multiple spatial scales in human modified landscapes are the backbone of conservation planning.

The rfbaA-D genes are involved in the rhamnose biosynthesis pathway and are believed to modify the O-antigen backbone of the cell wall LOS.

Through the ability to modify the alginate backbone to a high degree using click chemistry, click hydrogels can achieve controlled release of small molecules, biologics, antibodies, and nanoparticles.

Others chemically modify the PNA backbone with multiple arginine side chains to gain entry [31].

Improved delignification may be attributed to cleavage of ester intra-unit linkages within EGCG, and therefore in the backbone of the modified lignin polymer, and to efficient internal trapping of quinone methide intermediates by EGCG to out-compete benzyl ether cross-linking of lignin to structural polysaccharides.

In addition to the backbone of Minos, MiMIC is modified to carry a gene trap cassette flanked by two inverted ΦC31 attP sites.