Sentence examples for modify the active from inspiring English sources

Assuming that any of the newly discovered pathways are used at a frequency that is at least 10-fold lower than for the common pathways to WS, it is possible to estimate that only one in one thousand activating mutations would directly modify the active site.

Here, we designed fluorophore or biotin-coupled activity based-probes (ABP) that covalently modify the active center of MALT1.

The most effective TG2 inhibitors to date are small-molecule peptidomimetics featuring electrophilic warheads that irreversibly modify the active site catalytic cysteine (CYS277).

Genetics is used to modify the active site of a single kinase to render it distinct from all naturally occurring kinases.

Here, we provide biochemical evidence that carbamates covalently modify the active site of FAAH by adopting an orientation opposite of that originally predicted from modeling.

It is for this wide design space that ILs may be the entry into the fascinating vision of modifying physico-chemical properties without the need to structurally modify the active pharmaceutical ingredient itself.

Two inhibitors share a 4-halopyridine scaffold and act as quiescent affinity labels that selectively and covalently modify the active-site Cys residue.

Instead, it was necessary to modify the active-learning tutorial approach often used in physics classes to help students master qualitative reasoning.

NPI-0052 inhibits proteasome actinhibits covalently modifying the active site threonine residues of the 20S proteasome (Corey activity1999).

Wang, M., Rada, C. & Neuberger, M. S. Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID.

The V67L mutation is proposed to activate splicing by reducing the ensemble distribution of the intein structure and by modifying the active sites.