However, the precise substrates through which altered glutamatergic transmission results in drug modified synaptic plasticity and the development of addictive behaviors remain to be elucidated.
Astrocytes have prominent roles in modifying synaptic plasticity and formation of new synapses (see above).
Injury to the developing brain can modify synaptic mechanisms, change neuronal activity, interfere with normal development and plasticity, or alter the range of activities and experiences to which a child is exposed during development.
The molecular composition of the postsynaptic density is modified during synaptic plasticity, which forms the molecular basis of learning and memory.
These findings demonstrated that social environments can modify neurogenesis and synaptic plasticity in adult hippocampal regions, which is associated with alterations in spatial learning and memory.
ChR2 can selectively activate neurons and is able to modify neuronal circuits by inducing synaptic plasticity.
sAPP has been shown to support cell survival, neurite outgrowth, synaptogenesis, synaptic plasticity, can modify the response of neurons to injury, and can substantially rescue CNS deficits in an APP null mouse [34] [39].
However, the mechanisms through which ADDLs modify AMPA receptor trafficking and synaptic plasticity, as well as cognitive deficits, are not fully known.
"It's consistent with comparative genomics research indicating that the molecular basis of synaptic plasticity was modified in human evolution," he says.
Taken together with recent findings (see below), the present results suggest that in non-human primates antenatal DEX exposure might modify the early postnatal development and synaptic plasticity of PFC with possible functional consequences.
