Sentence examples for modify protein function from inspiring English sources
These effector-pathways individually block viral transcription, degrade viral RNA, inhibit translation and modify protein function to control all steps of viral replication [4] [5].
Chemical genetics, a research paradigm for using small chemical compounds to modify protein function(s) to alter phenotype(s) of cells or entire organisms, is emerging as a powerful tool not only for uncovering molecular mechanisms underlying important biological phenomena but also for exploring new therapeutics [11], [12].
Put more precisely, changes in the primary amino acid sequence can affect the pocket surface electrostatic potential and modify protein function through steric hindrance.
We considered these genes to be highly polymorphic and were interested in addressing whether they might contain an unusual number of changes that could modify protein function.
We then use these genetically encoded DARPins to modify protein function in different animal models, either by degrading or re-localizing fluorescent proteins in developing organisms.
They are frequently smaller than 200 nt in size, and act to regulate mRNA translation/decay but can also bind to proteins and thereby modify protein function (recent reviews [ 1, 2]).
In the second pathway, NO covalently and reversibly forms adducts with free thiols of cysteine residues within proteins and hence directly modifies protein function [5].
Histone deacetylase 3 removes acetyl groups from lysine residues, thereby modifying protein function.
Therefore, it is important to determine phosphorylation sites in poplar proteins, and to determine the roles of these phosphorylations in modifying protein function during growth and development.
NO generated by NOS reacts with intracellular glutathione to form nitrosoglutathione, an intracellular reservoir, which in turn transnitrosylate protein thiol to form nitrocysteine, thus modifying protein functions [19].
This is > 10,000-fold smaller than the smallest forces known to modify protein molecule function.
