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We also describe strategies for modifying the genome to generate protein fusions to report on and modify protein behavior.
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Our studies show that crown ethers can modify protein surface behavior dramatically by stabilizing either intra- or intermolecular interactions.
These modifications directly modify protein expression.
Exponentially modified protein abundance index.
demPAI: the values of exponentially modified protein abundance index.
The observation that either LRRK protein could significantly enhance canonical Wnt signaling upon co-expression with additional Wnt pathway components suggested that the co-transfected proteins modify the behavior of LRRK1 and LRRK2.
Different aspects of protein behavior can be rationalized by studying how the energy landscape of a single chain in the marginally compact phase can be modified.
Harrison's 3000 lines of code--he wrote much more than that, then pared it down--modify the very guts of Rosetta, allowing scientists to specify pH and calculate the effect of pH on the energies that underlie protein behavior.
The topological implications of the observed scale-free properties in biological networks would indicate that the best therapeutic targets to modify network behavior would be the genes (or proteins) corresponding to the hubs in the network.
These and other studies that were based on the well-established finding that stromal cells modify the behavior of tumor cells and vice versa have elucidated signaling molecules, proteases and other proteins that are crucial to this interaction.
They sense different concentrations of carbohydrate and protein macronutrients and they modify their feeding behavior in response to changes in dietary conditions.
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CEO of Professional Science Editing for Scientists @ prosciediting.com