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Identification of reversible factors demonstrated to modify lung function is a priority, as this may lead to new interventions to prevent chronic lung disease.
Intratracheal MSC treatment did not modify lung function or histology.
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The role of airway remodeling in modifying lung function response to improved air quality is supported by our previous finding of an interaction between ΔPM10 and polymorphisms in apoptosis-related gene (Imboden et al. 2009), as well as by the fact that the observed interactions in this study were restricted to average BMI, which is likely to reflect chronic effects in ΔBMI.
Patients receiving chemotherapy for lung cancer usually modify their lung function during treatment with increases in forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) and decreases in lung diffusion for carbon monoxide (DLCO).
Microsomal epoxide hydrolase (EPHX1 ) has a putative dual function for enzyme activity which possibly modifies lung cancer risk.
Multiple epidemiological studies have suggested that asthma risk is determined by prenatal and/or early life exposure to pollutants and allergens that modify later life lung function and T helper cell allergic phenotype [11].
Mechanisms leading to the development of COPD are poorly understood, and there are currently no effective therapies that modify long-term lung function decline in patients with the disease.
For instance several factors that might be expected to vary with socio-economic status have been reported to modify children's lung function, these include area of residence, outdoor air pollution, type of heating or cooking fuel used, crowding and maternal smoking during pregnancy [ 12].
Correlation between the modified Chrispin-Norman score and lung function was assessed by using a Spearman correlation coefficient.
Data for the adjusted Chrispin-Norman score are intraclass correlation coefficients The correlation between the observers' modified Chrispin-Norman scores and lung function is presented in Table 4.
Atopy or FENO-levels did not modify the effects of adiposity on lung function.
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CEO of Professional Science Editing for Scientists @ prosciediting.com