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In addition, this eNOS polymorphism may modify lead toxicokinetics.
Iron metabolism gene variants modify lead metabolism such that HFE variants are associated with increased blood lead levels in young children.
Other research in this area has shown that genetic polymorphisms in iron metabolism genes not only modify lead kinetics, but also confer variable host response to lead exposure.
The gene that encodes gamma-aminolevulinic acid dehydratase (ALAD) has a polymorphism that may modify lead toxicokinetics and ultimately influence individual susceptibility to lead poisoning.
Because of the well-described inverse relationship between iron stores and lead absorption (Kwong et al. 2004), iron metabolism genes are potential candidates to modify lead absorption and stores.
Although controversy remains on the influence of the VDR genotype on bone mineral density, the data suggest that variant VDR alleles modify lead concentrations in bone, either by influencing lead content or calcium content or both.
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