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Osteopontin (OPN) is an abundant bone extracellular matrix protein with roles in mineralization, cell adhesion and cell migration, and it has putative consensus sequence sites for cleavage by PC5/6, which may modify its function in bone.
A gene of interest is targeted to modify its function, and an enzyme cuts that gene's DNA sequence, breaking the structure of the DNA.
These additional interactions might in principle modify its function.
It is therefore interesting to speculate that KCa3.1 also localises with the various Gαs receptors that modify its function.
AdcA being a protagonist of the endocytic pathway, its phosphorylation could modify its function and interfere with the regulation and fate of some key membrane targets (e.g. ion transporters) involved in the stress response.
The differences in amino acid sequences of MSP that were predicted in this study can consistently modify its function during the pathogenesis of periodontal disease with regard to binding capacity to cells and extracellular matrix and to evasion of host responses by T. denticola.
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In this article, an integrated modification method was developed by proportionally using recycled crumb rubber (CR) from vehicle tyre and polyethylene (PE) from wasted green house plastic film in the bitumen in order to modify its functioning in pavements.
This result raised the possibility that change in the stoichiometry of the hPAF complex following gene amplification or gene expression deregulation influenced the subcellular localization of hPAF complex, therefore modifying its function.
These results demonstrate that polyP not only co-purifies with TRPM8 protein, but also modifies its function, and is thus directly involved in the regulation of TRPM8 channel activity.
The CDC37 protein physically interacts with the HSP90 protein and modifies its function by the recruitment of other co-chaperones (Roe et al. 2004; Röhl et al. 2013).
Secondly, the growing information on the structure/function relationships of membrane proteins indicates that the lipid bilayer often does not simply hold the protein in place but can also intimately interact with the protein, modifying its function [6,7,8].
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