Sentence examples for modify gene function from inspiring English sources

DSBs trigger DNA repair mechanisms and can result in loss of gene function by error-prone non-homologous end joining (NHEJ), or they can be exploited to modify gene function or activity by precise homologous recombination (HR).

We found that the massive structural rearrangements of primate-specific PRDM7 gene greatly contributed to modify gene function.

However, the ability to understand and modify gene function for crop improvement is hindered by the lack of available genomic resources.

Utilizing cell based transgenesis with site specific modification of the pig genome, one can be begin to modify gene function for the enhanced development of novel disease models in several research areas such as cardiovascular disease, xenotransplantation, and neurodegenerative diseases.

In addition, other factors such as copy number variation or indeed epigenetic mechanisms (e.g. DNA methylation, histone modification and microRNAs) may also modify gene function and/or expression profiles affecting these pathways and modulating disease risk accordingly.

In broadest terms, single-copy loss of a suppressor gene can be sufficient to modify gene function and promote tumorigenesis (classical haploinsufficiency), while in other tumors, the loss of two alleles is required (two-hit paradigm of Knudson) (Knudson, 1971).

This observation can be explained by the fact that many mutations may or may not modify gene functions but do not affect their expression.

Given that these elements display mobility, they are important in plant evolution, through creation of novel genes or modifying gene function (Bennetzen 2000).

Moreover, the discovery of novel genes or modified gene functions that make each species unique can now be performed by simple EST analysis or trait mapping.

The first genetic longevity studies mainly focused on lifespan regulating loci that emerged from animal models 22. Lifespan extension in animal models was obtained by applying caloric restriction or by modifying gene functions (mutagenesis) using RNA interference, knock-out or overexpression of single genes (GenAge; http://genomics.senescence.info/genes/) 23.

TE insertions near genes can modify gene expression patterns, while insertions within genes can interrupt transcription and gene function [ 23].