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The TTSS encoded in SPI-2 enables S. enterica to modify functions of the host cell, and thus is essential for the survival and replication of S. enterica inside host macrophages, which is vital for causing systemic infection [14].
Moreover, none of them provides an integrated solution for clinical researchers without any knowledge in programming, as well as a plug-in architecture platform with the possibility for developers to add or modify functions without need to recompile the entire application.
By integrating all functions into a user-friendly desktop application, BioSunMS provided a comprehensive solution for clinical researchers without any knowledge in programming, as well as a plug-in architecture platform with the possibility for developers to add or modify functions without need to recompile the entire application.
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PSR postulates that changes in the subcellular location of eukaryotic duplicate proteins can positively modify function and therefore be beneficial to the organism.
Thus, it is of great interest to understand the detailed mechanisms by which different UBLs are directed to their targets, and thereby modify function.
Gene duplication is a key evolutionary mechanism providing material for the generation of genes with new or modified functions.
Over the past few years, novel designed zinc fingers with modified functions led to a variety of applications [29], [31].
Within these constraints, existing enzymes are recruited during evolution to perform new or modified functions, while often maintaining some aspects of the ancestral function.
Via mutations, domains acquire modified functions that contribute to the fitness of cells and organisms.
The small sub-unit has evolved under strong constraints, preventing the acquisition of new or modified functions [ 29, 30].
Genetic polymorphisms can contribute directly to the variety in phenotypic drug sensitivity by modifying functions of the related genes.
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