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However, GGTI-298 alone (10 µM) did not significantly modify expression of MHC-I and in particular HLA-A0201 (Figures 3A and 3B).
Temperature variation is one of the most commonly encountered environmental changes, and it has been reported that bacteria can modify expression of at least 10% of their genes in response to an increase or decrease in growth temperature [8], [9], [10].
Peroxisome proliferator activated receptors (PPARs) are steroid hormone nuclear receptors that modify expression of several genes.
We also studied whether CAP1/ Prss8 inactivation would modify expression of tight junction proteins.
Unfortunately, we showed that quercetin does not modify expression of TRAIL-R1 (Supplementary Figure S3).
In sharp contrast, at these levels of confidence and threshold, docetaxel did not modify expression of any gene.
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Signal transduction leads to modifying expression of defense-related genes and defense mechanisms against BPH, including sieve tube sealing, production of secondary metabolites, and induction of proteinase inhibitor.
Previous studies have shown that combination therapy modifies expression of hundreds of genes in vitro and in vivo.
This observation suggests that modified expression of a relatively small subset of ROS-associated or -induced genes may suffice for a degree of tolerance to ROS.
Firstly, FGFR3 activating mutations affect input signals (modified expression of other growth factors and membrane bound receptors, biochemical properties of the ECM).
In turn, modified expression of several of these molecules, including CaMK [2], AMPK [3], [4], PGC1α[5], [6] and β[7], and PPARδ [8], directly alters metabolic outcomes in mice including adiposity, glucose tolerance, oxidative capacity, and endurance (or resistance to fatigue).
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