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Cells, which were cultured without animal-derived agents and also treated with a proteolytic enzyme to transiently modify cell surface adhesion proteins, were infused 24 h after transient middle cerebral artery occlusion (MCAO).
In addition, lactic acid has a stronger bacteria inhibitory activity compared to the commonly used hydrochloric acid at the same pH value due to its higher acid dissociation constant, ability to modify cell surface properties and to induce cell membrane damage (Wang et al. 2014).
Instead, they may function to modify cell surface structures during infection.
Cells treated with a proteolytic enzyme (pronase) could transiently modify cell surface adhesion proteins [ 168].
In addition to these two groups, they also analyzed the distribution of BM-MSCs treated with a proteolytic enzyme named Pronase (Roche, Mannheim, Germany), instead of trypsin, to transiently modify cell surface proteins.
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Future directions in terms of developing dynamic approaches to modify cell surfaces have been discussed in brief.
The technique of metabolic oligosaccharide engineering has been used to disrupt glycan biosynthesis, chemically modify cell surfaces, probe metabolic flux inside cells, and to identify specific glycoprotein subtypes from the proteome.
The possibility to modify cell surfaces with engineered sialic acids in vivo offers the opportunity to target therapeutic agents to sites of high sialic acid concentration in a variety of tumors.
Together with H. pylori-activated matrix-metalloproteases (MMPs) of the host cell [ 104, 106], several modes of shedding and modifying cell surface molecules are now known.
In particular, it was discovered that the majority of natural antibodies against cancer cells are IgMs, directed against new carbohydrates on post-translationally modified cell surface receptors of malignant cells (84, 85).
The peptidylarginine deiminases appear to have been acquired by animals from bacterial enzymes that modify cell-surface proteins.
More suggestions(15)
changing cell surface
alters cell surface
modify cell wall
modify cell cycle
modify cell division
modify receptor surface
modify cell morphology
modify cell dimensionality
modify cell growth
modify cell viability
modify cell fate
modify cell shape
modify cell function
modify cell proliferation
modify fiber surface
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