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Up to now, scientists have discovered "modifiers" that modify a specific locus on chromatin, for example, methyltransferase G9a methylates histone H3 at lysine 9. We also know DNA/histone modifications have their specific reader proteins – for example, chromodomain-containing protein recognizes methylated lysine.
Parameters can be varied independently to modify a specific agent's behavior (e.g. walking speed, memory, decision rules etc).
In particular, during the in vitro culture inside bioreactors, the biophysical forces may modify a specific cell status of force equilibrium, named "tensegrity," inducing, via mechanotransduction, changes to the transcriptional profile.
Just as genetic architecture describes the genomic influences underlying a phenotypic trait, epidemiologic architecture describes population-level phenotypes, exposures, and ancestry that modify a specific genetic effect and influence its population impact.
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?When one task is reading or modifying a specific variable, the other tasks should not access this variable at the same time in order to avoid potential intervention.
The research, performed in mice, involved modifying a specific class of immune cells to patrol the body for cancer and send a signal through blood or urine when they found trouble.
The biosynthesis of these compounds is based on ordered assembly lines of multi-domain modules, each extending and modifying a specific chain-elongation intermediate before transfer to the next module for further processing.
The biotinylation reaction modifies a specific lysine residue at the biotin ligation site (bls: GLNDIFEAQ KIEWHE, the underline is the ligation site).
Members from the R-S-E clade include the cholera toxin, which modifies a specific arginine in a mammalian Gα subunit, the Bordetella pertussis toxin which modifies cysteine, the Clostridium botulinum C3 toxin that modifies asparagine, and the Photobacterium luminescence toxin which modifies glutamine in target proteins [ 145, 148].
Further, the ability to modify Ad vector tropism to target specific tissues (termed transductional targeting) is well established.
The input signal can be amplified through the MAPK cascade to modify a set of specific downstream target proteins by the way of phosphorylation [ 12].
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