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Su, Y. et al. Neuronal activity modifies the chromatin accessibility landscape in the adult brain.
Epigenetic regulation, which modifies the chromatin architecture to facilitate gene expression at specific loci of the genome, is a rapidly developing field of research.
If a TF modifies the chromatin structure through chemical modifications of histones or remodeling of nucleosomes, the effect of this TF on other TFs will be less specific (as it could affect all binding sites in the neighborhood) and less likely to follow strict rules.
1, 2 Inhibition of HDAC increases histone acetylation levels and, thus, modifies the chromatin structure and alters gene expression.
In addition to acetylating SOX4, we tested whether KAT5 modifies the chromatin structure thereby increasing TF access to the Cald1 promoter.
The DCC, functional only in males, modifies the chromatin structure of the X chromosome by altering its pattern of histone acetylation [ 12, 13].
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PcG proteins are recruited to specific regulatory elements to modify the chromatin surrounding them.
Recent genetic and biochemical studies have elucidated the mechanisms of NuRD action in modifying the chromatin landscape.
These roles may be partially mediated by Myc's capacity to modify the chromatin landscape on a global scale.
Epigenetic alterations of chromatin such as histone acetylation do not alter the DNA sequence but modify the chromatin architecture and its accessibility, resulting in repressed gene transcription.
Preceding the binding of STAT6, several epigenetic mechanisms were observed that are known to modify the chromatin architecture of a gene.
More suggestions(15)
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