Sentence examples for modifies splicing of from inspiring English sources

The efficacy of some frontline anti-epileptic drugs, which often work through stabilizing channels in the inactive state, has been suggested to be influenced by a polymorphism that modifies splicing of NaV1.1 leading to altered inactivation (Fletcher et al., 2011).

We sequenced the full DYSF cDNA and investigated antisense oligonucleotides (AONs) as a tool to modify splicing of the mRNA transcripts in order to process out mutant sequences.

Overall our results demonstrate that deregulation of lamin B1 expression induces modified splicing of several genes, likely driven by raver-2 overexpression, and suggest that an alteration of mRNA processing could be a pathogenic mechanism in ADLD.

Overall, our results suggest that deregulation of lamin B1 induces modified splicing of several genes, which is at least partially driven by the enhanced expression of raver-2, a RNA-binding protein (RBP) that modulates the splicing repressor polypyrimidine tract binding protein (PTB) (17– 20).

Retrocopies provide the means for modifying splice patterns of genes [ 44], potentially adding entirely new protein coding sequences, and contributing non-protein coding RNA or regulatory sequences, thereby expanding the possibilities to shape gene evolution.

Morpholinos can also modify the splicing of pre-mRNA.

These conserved small RNA regulators modify alternative splicing of many transcripts (Bachellerie et al, 2002).

This approach is effective in modifying aberrant splicing of other pseudoexons 36, 37, 39, 40 (reviewed 41, 42).

Of note, inflammatory mediators may also modify the splicing of beta cell genes [ 100], which opens interesting possibilities for the imaging of inflamed beta cells.

Two distinct mechanisms were identified by which FOX2 modifies the splicing pattern of target genes in cancer [ 55].

► Alternative splicing modifies the properties of TMEM16A-associated ion channels.