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Also, Durieux and colleagues have shown that manipulation of the electron transport chain only in neurons modifies lifespan of the worm [ 10].

Recent reports have demonstrated that in C. elegans miRNAs modify lifespan [ 17, 21, 22], although the mechanisms and direct biological targets of the miRNAs remain elusive.

Insulin/IGF like signaling is a key modulator of lifespan through its control of a transcriptional regulatory network and represents a potential target for miRNAs to modify lifespan.

In summary, AOX expression did not consistently or significantly modify lifespan in Drosophila.

This demonstrates that proteomic approaches can be used to identify genes that modify lifespan.

The second complementary screen, using a library of flies with unique GS element insertions, identified genes, which when transcriptionally up- or downregulated modified the lifespan of flies expressing Aβ1 42.

While the lifespan of the genetically modified strains was found to be unaffected under standard growth conditions, increased exogenous hydrogen peroxide stress in the growth medium markedly reduced the lifespan of the PaCatB deletion strain but extended the lifespan of PaCatB over-expressors.

Once emigrated, the lifespan of neutrophils can be modified by the local inflammatory environment (Fox et al, 2010; Geering & Simon, 2011; Fig 2B).

Identification and utilization of genetically modified MSCs, having a 'safe harbor' integration, is restricted because of the limited lifespan of primary MSCs in vitro.

A modified Ercc1 knockout mouse model expressing a liver-specific Ercc1 rescue transgene to prevent hepatic insufficiency shows an increased lifespan of 12 weeks.

Using a modified C. elegans liquid lifespan assay with live E. coli OP50 (see Experimental procedures), we observed that RIF significantly increased lifespan of wild-type worms (Fig. S2A, details in Table s3).