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pRb undergoes cell-cycle-dependent phosphorylation during G1, and this modifies its interaction with at least some members of the E2F family, which regulates the transcription of many genes required for S phase (Kaelin et al, 1992).
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Similarly, in previous studies using immunoprecipitation, mutations in pyrin did not modify its interaction with PSTPIP1 [5].
In this scenario, reduction of the hydrophobicity of the HC may modify its interaction with the cell membrane and thereby decrease the rate of α-cleavage.
Once HMGB1 is modified, its interaction with chromatin diminishes.
We hypothesized that such a mutation might alter MAVS conformation, thus modifying its interaction with downstream signalling molecules.
The amount of F-actin/synapsin I bundles recovered by low speed sedimentation was increased by staurosporine by approximately 30% at 5 µM (Fig. 3B), indicating that binding of the kinase inhibitor to the ATP binding site of synapsin I modifies its molecular interactions with the F-actin-based cytoskeleton.
However, unlike ubiquitin it does not mark the protein for degradation, instead it modifies its substrate's interaction with partner proteins.
The interaction of the electron's magnetic moment with the magnetic field created by its motion (the spin-orbit interaction) modifies its energy and is proportional to the combination of the orbital angular momentum and the spin angular momentum.
But there are two other characteristics of science that are also important when it comes to deploying its knowledge for the benefit of public policy and society: that scientific knowledge is always provisional knowledge, and that it can be modified through its interaction with society.
When a rock propagates down a forested slope, it hits trees and these interactions modify its trajectory.
It was found that the pKa of the low-molecular weight molecule (LMWM) may be modified by its interaction with the polyanions, changing from 3 to 5, due to electric charge compensation.
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CEO of Professional Science Editing for Scientists @ prosciediting.com