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The theorem can be applied with two procedures based on the decomposition of the original signal only or the previously decomposed (modified) signals in sequence.
Flagellin genes (coding for a PAMP-bearing protein) were present in O. anthropi and B. abortus, even though both predicted proteins are modified in the consensus sequence recognized by TLR5 [27].
A new CSFV-BAC (pBeloR26) derived from the Riems vaccine strain has been constructed and subsequently modified in the E2 coding sequence, using the targeted recombination strategy to enable rescue of chimeric pestiviruses (vR26_E2gif and vR26_TAV) with potential as new marker vaccine candidates.
Substantial structural modifications were necessary to engineer this antigen, with the 2F5 epitope replacing a helix in the native scaffold and with 15% of the native scaffold sequence being modified in the design stage.
The substorm sequence was modified in 1970 by the addition of a growth phase prior to the onset of the expansion phase (McPherron 1970).
In addition, 4 bases of the intron sequence were modified in conjunction with the loop.
The original coordinates of the ancestral sequence were modified in order to provide with Cβ coordinates to those residues without them.
DNA sequence 5 was modified from DNA sequence 2 in the second minor groove linker binding site portion to give a more favorable GG intercalation step, so the preference of 2 and 3 for DNA sequence 5 over DNA sequence 2 is not altogether surprising.
DNA sequence 3 is modified in the major groove binding site portion to allow for a GA intercalation step as well, and this sequence was by far the least preferred.
The peptide sequences were modified in order to enhance their HLA binding affinity [ 19, 20].
About 2.5% of the total number of CHH sequences was modified in EHB and about 1.1% in AHB (Table 1).
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