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Adequately powering an intervention study with consideration of mediators and modifiers will require a larger sample size and is beyond the scope of this project.
As an adjunct to predictive testing for a high risk BRCA1 or BRCA2 gene mutation, more individualized risk estimates that take into account additional genetic and environmental modifiers will require a more detailed understanding of how these various risk factors interact.
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Likewise, the search for genetic modifiers of risk will require large numbers of samples, as will the establishment of typical tumour characteristics of cancers linked to BRCA1 or BRCA2 mutations.
Variables concerned with treatment effect modifiers will necessitate consideration of an alternative study design [ 7].
Genetic modifiers and/or environmental risk factors may influence the epilepsy subtype or severity; this will require more systematic studies in the future.
Thus far we are not even sure whether modifiers of BRCA-conferred risk actually exist, but some suggestive associations have been reported, which will require independent confirmation.
Others will require Congress.
The future will require thought".
(Jerusalem will require immense creativity).
Adaptation will require redistribution, too.
That will require painful cuts.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com