Sentence examples for modifiers will provide from inspiring English sources
Epigenetic mechanisms involved in disease progression serve as therapeutic targets; therefore, identifying epigenetic modifiers will provide major advances in the treatment of NAFLD.
In many cases, the presentation of risk estimates in a comprehensive table (for example, see Bell and Dominici 2008, their Table 5) that account for alternate model specifications and effect modifiers will provide the details necessary to inform a risk assessment.
The identification of convincingly validated modifiers of breast cancer risk for BRCA1 and BRCA2 mutation carriers will help to understand the biology of hereditary breast tumors and, in the case of BRCA1-mutation-associated risk modifiers, will also provide candidate low penetrance genes for 'sporadic' basal cell breast cancers because of their similarity to BRCA1-related breast tumors [ 23, 24].
The identification of withanolide E as a novel and selective modifier of HSP90 client protein interactions will provide a better understanding of the role of HSP90 in TRAIL signaling.
In addition, the publication of convincingly validated SNPs associated with breast cancer in the general population [ 22] will provide some new candidates to test as modifiers of breast cancer risk among BRCA1 or BRCA2 mutation carriers.
In the second level analysis we will provide multivariate statistics in order to take into account effect modifiers such as basal level of motor development, family compliance and time of training.
Finally, given the frequency of the expansion in both ALS and FTLD, this population will provide an ideal group to elucidate the role of genetic and environmental modifiers contributing to the heterogeneity of disease.
Identification of these modifier genes and further comparative functional analysis utilizing mice deficient in Hif1α and Hif2α will provide insight into the precise molecular mechanisms leading to the development of VHL-associated pancreatic disease.
Studies of the mitochondrial retrograde signaling will provide insight into mechanisms of genetic interactions and facilitate the identification of potential modifier genes.
Only digging will provide proof.
