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In theory, the identification of new biomarkers and modifiers will lead to a more precise diagnosis and then to individualized phenotypes, enabling a personalized therapy [2].
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Since toxoplasmosis is a complex disease, multiple genes and modifiers will contribute to end stage pathology.
The new mouse model described here may allow the identification of genetic and epigenetic modifiers of the MFS phenotype, which in turn will lead to a better understanding of the clinical variability of the disease, and of the physiology of pulmonary, cardiovascular and skeletal systems.
The identification of genetic modifiers of breast cancer risk for BRCA1 and BRCA2 mutation carriers will lead to an improved understanding of breast cancer and may prove useful for the determination of individualized risk of cancer amongst carriers.
Such a molecular dissection of cell signalization involved in bronchial carcinogenesis will lead in a near future to the design of "biological modifiers" interfering with those signalizations.
Phil Jagielka will lead England.
Ryan Theriot will lead off.
We will lead the way.
Who will lead it?
But who will lead?
This will lead into….
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