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There is an obvious lack in the understanding of causes behind and modifiers of this obesity-related inflammatory activity and environmental as well as genetic factors may be considered to play a role in the aetiology of this condition.
The other variables were potential confounders or effect modifiers of this association.
We sought to identify genetic modifiers of this process in erastin-resistant cell lines.
However, the identities of potential HPE modifiers of this type are unknown.
This study provides evidence that modifiers of this trait remain to be identified.
Important modifiers of this relationship are pH, CO2 concentration and the intraerythrocytic level of 2,3-diphosphoglycerate (2,3-DPG).
Similar(41)
A genetic correlation with clinical and pathological parameters has also been made, identifying two previously uncharacterized modifiers of the phenotype of this mutation.
For example, screens in yeast, Caenorhabditis elegans and Drosophila melanogaster expressing an introduced fragment from human huntingtin consisting largely of polyglutamine have yielded a number of modifiers of the effects of this fragment [ 47- 50].
The second aim of this study was to assess potential modifiers of the laboratory field association.
One aim of this screen was to identify evolutionarily conserved modifiers of the p53 signaling pathway.
Furthermore, we aimed to assess sex as a potential effect modifier of this association.
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