Sentence examples for modifiers of sensitivity from inspiring English sources

Furthermore, these screens revealed secondary genetic modifiers of sensitivity, yielding a SRC inhibitor-based combination therapy for KRAS/PIK3CA double-mutant colorectal cancers (CRCs) with clinical potential.

When we determined the relationship between survival and radiation-induced chromosome aberration frequency, a measure independent of most other modifiers of sensitivity, we observed a direct relationship between ploidy and mean lethal aberration frequency.

Taken together, these data suggest that the presence of dMMR/MSI may be one important modifier of sensitivity to cytarabine, although multiple other genetic and epigenetic factors are also important particularly given the multiple mechanisms of action of this drug (discussed below).

Mcl-1 and Bcl-2 are known modifiers of drug sensitivity.

Informational modifiers (such as suppressors of nonsense mutations in classical screens [e.g., Hodgkin et al., 1989], and modifiers of germline RNAi sensitivity in this experiment) alter the effect of the initial perturbation in a non-gene-specific manner, while gene-specific modifiers reveal functional features of the targeted locus.

The best way to regard the action of sensitivity factors is as multiplicative modifiers.

Molecular oxygen has long been recognised to be a powerful modifier of cellular radiation sensitivity.

In addition, in our in vitro work, we found that both epigenetic modifiers increased the sensitivity of the cancer cell lines to cisplatin, suggesting that they may have an important role in platinum-resistant ovarian cancer.

Beginning of sensitivity to light.

Given that it is currently unknown whether these candidates are genuine modifiers of prion disease, we are unable to determine the sensitivity, specificity and predictive value of the SCA.

Modifiers of large effect can become fixed, and also invade, in a wider parameter range than modifiers of small effect.