Sentence examples for modifiers of high risk from inspiring English sources

Luthar's influential 50-year review of the resilience literature (2006) concludes with two salient recommendations for further study and application: First, given the long and growing list of protective and vulnerability factors identified as modifiers of high risk circumstances, there is a practical need to prioritize which ones are most important.

Extended families with multiple cases are a proven means of discovering genes that when mutated convey a high risk of disease [ 25], and are an efficient sampling design for identifying mutation carriers for studies of genetic and environmental risk modifiers.

High risk of bias was considered present when no descriptions of patient selection or setting, or no description of outcomes, predictors, or effect modifiers were found in the report.

This recent success in identifying both genetic and environmental modifiers of AMD susceptibility has prompted the development of algorithms for identifying individuals at particularly high risk for AMD based on some combination of environmental and genetic risk factor data[11], [14] [18] (Table 1).

Carriers of germline mutations in DNA mismatch repair (MMR) genes have a high risk of colorectal cancer (CRC), but the modifiers of this risk are not well established.

High body fat = high risk of cancer.

Darius was at high risk of death.

Germline genetics, gender and hormonal-signaling pathways are all well described modifiers of cancer risk and progression.

Hence the finding of an association between MMP1 and MMP3 genotypes and RCC risk represents the first examples of genetic modifiers of RCC risk in VHL disease.

We observed that variants of MMP1 and MMP3 were significant modifiers of RCC risk (and risks of retinal angioma and cerebellar haemangioblastoma) in VHL disease patients.

Identifying modifiers of CRC risk for carriers of MMR gene mutations is important for understanding carcinogenesis.