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Extragenic modifiers may work by affecting, in trans, the expression level of the targeted gene.
We added the following to the Results section: "Extragenic modifiers may work by affecting, in trans, the expression level of the targeted gene.
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As reviewed herein, specific epigenetic modifiers, such as H3K4 methylation modifiers, may play fundamental roles in orchestrating cellular epigenomes whose genomic sequences are identical.
Allelic heterogeneity and genetic modifiers may influence the phenotypic variability of VHL disease (31– 31).
This suggests also that epigenetic modifiers may act as novel targets for therapy.
It has to be considered that modifier genes may each contribute small effects to a disease phenotype, but may work in concert with environmental influences, resulting in an amplified or diminished consequence.
And that may work.
But it may work.
That may work.
It may work, but it may not.
It may work, it may not, Steve.
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