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These results suggest inflammation and/or stratum corneum hydration may be involved in the TEWL phenotype, but that other genetic modifiers may influence the onset and severity of these phenotypes due to Scd1 deficiency.
Many cases of familial RCC do not have mutations in known RCC susceptibility genes and there is evidence that genetic modifiers may influence the risk of RCC in VHL disease patients.
Allelic heterogeneity and genetic modifiers may influence the phenotypic variability of VHL disease (31– 31).
Because many factors including T-DNA copy number, insertion site, local features, and differential settings of epigenetic modifiers may influence transgene activity, comparisons of chromatin patterns between different loci may be difficult.
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Furthermore, genetic modifier effects may influence the risk of RCC in VHL disease [10] [11].
Genetic modifiers and/or environmental risk factors may influence the epilepsy subtype or severity; this will require more systematic studies in the future.
The objectives of this systematic review are to examine whether the augmentation of pharmacological treatments with psychotherapy is associated with higher effectiveness compared to pharmacotherapy alone and identify possible treatment effect modifiers, i.e. factors that may influence the size of effects of augmentation of pharmacological treatments with psychotherapy.
It is not clear why the brother had a milder retinal phenotype and a normal BMI at the age of 21, although it is possible that environmental factors or other genetic modifiers may have influenced his phenotype.
This may influence their preference.
Therapeutic interventions may influence hedonic eating behavior.
Genetic variability may influence hedonic hyperphagia.
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