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The individual genetic background (modifiers) may contribute to the broad spectrum.
This complexity is not surprising given that additional modifiers may contribute to the net effects of Hsp90 inhibition.
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3, 4 Moreover, for any given disorder, multiple modifier genes may contribute to the phenotype in a cumulative way and have the potential to alter penetrance, expressivity, pleiotropy, and severity, including age of disease onset and progression rate.
These cases reinforce the hypothesis that modifier genes and/or epigenetic factors may contribute to clinical presentations of Pompe disease.
The other modifier factors such as nuclear modifier genes, environmental and epigenetic factors, and personal lifestyles may contribute to the development of hypertension in these subjects carrying the 4435A>G mutation.
This provides a possible mechanism of selective neurodegeneration in the striatum, although other mechanisms may contribute as well; including striatal-enriched post-translational modifiers of Htt such as Rhes (Subramaniam et al., 2009), or non cell-autonomous mechanon cell-autonomous 2014).
Electron beam irradiation was applied to recycled LDPE (LDPER) to provide formation of free radicals and some functional groups that may contribute to creation of strong chemical bonds between polymer modifier and bitumen.
Rare monogenic diseases cannot be attributed to variants that are common, though such variants may contribute to the risk of common complex diseases, or act as modifiers of rare disease.
The public may contribute.
Environmental factors may contribute too.
This may contribute to inflationary pressures.
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