Sentence examples for modifiers may act from inspiring English sources
This suggests also that epigenetic modifiers may act as novel targets for therapy.
We reasoned that histone modifiers may act cooperatively with the Brm complex in type II neuroblast lineages and the phenotype may be masked due to the presence of the functional Brm complex.
Since the CHEK2 1100delC variant does not show clear co-segregation with disease it is considered to be a modifier, and may act in cooperation with yet unidentified high-penetrance genes or together with multiple low-penetrant genes as part of polygenic inheritance.
While not associated with PCOS itself, genetic variation in DNAJB1 and perhaps DKK1 may act as modifiers, affecting the metabolic and androgenic pathways of PCOS, respectively.
Modifiers of a cancer phenotype may act either intrinsically or extrinsically on the salient cell lineage.
Tau haplotyping indicated that specific haplotypes of the wild-type allele may act as modifiers of disease presentation.
The first, and perhaps the more straightforward, relates to the control of variables that either represent potential confounders or may act as modifiers of the effects under investigation (Spurgeon and Gamberale 1997).
The aim of our study was to collect information on the genes and pathways that may act as modifiers of the early stage of mutant htt toxicity in HD such as neuron dysfunction.
However, use of DNA microarray analysis should soon shed some light as to the genetic factors that may act as modifiers in the disease phenotype predicted by the detection of germline mutations in MMR genes.
Familiarity questions (n = 4) explored issues such as personal or family experiences of mental disorders and predictions about future vulnerability (factors that may act as modifiers of reactions); these were supplemented by questions that explored views on likely help-seeking and probability of self-disclosure.
These data demonstrate that altered SL metabolism can impact cyst growth, suggesting that genes involved in SL metabolism may act as modifier genes to influence disease severity.
