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The advantages of the early initiation of therapy combined with the introduction of newer antirheumatic agents (such as the TNF biologic response modifiers) have shifted treatment models toward the earlier and more timely use of DMARDs [ 4] and biologic therapy [ 5, 6].
Similar(59)
Those winds have shifted.
The dynamics have shifted".
Priorities have shifted.
But things have shifted recently.
"They have shifted their tactics.
Consequently, his sights have shifted.
Lately, though, signs have shifted.
Now they have shifted yet again.
We have shifted to a transition phase.
But the winds of change have shifted.
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