Sentence examples for modifiers has led from inspiring English sources

In Zhang's hands, addition of these "modifiers" has led to dramatic improvements in cloning wiping out barriers present in the adult cells.

Additional analysis of PEV modifiers has led to an estimate that as many as 150 genes affect chromatin-related gene silencing [5].

One of the key advantages of the C. elegans system is the possibility of rapid and comparably cheap modifier screens; this has led, for example, to the identification of sut-2 as being required for tau neurotoxicity [ 30].

Furthermore, the observation of muscleblind (mbl), another RNA-binding protein, as a modifier of toxicity has led to the discovery that the SCA3 transcript itself is toxic (Li et al, 2008).

This 'missing heritability', as it has been termed [ 10], together with the increasing knowledge of modifier genes and gene networks, has led to the suggestion that epistasis may make a substantial contribution to the overall levels of genetic variation [ 5] and that the contribution of additive variance may have even been overestimated [ 11].

Moreover, despite the presence of identical FBN1 mutations, a remarkable intrafamilial variability is observed, in addition to a marked interfamilial variability, which has led to the hypothesis that modifier genes must be involved.

Herceptin is therefore one of the first biological response modifiers to have shown some clinical success and as such has led to its approval in the treatment of patients with c- erbB-2 overexpressing breast cancers.

Increased understanding of a congenital form of the syndrome, the frequency of the side-effect and the variability in its severity has led researchers to suggest that individual variability in cardiac repolarization reserve is among the major risk modifiers [ 74].

The presence of a nearly identical copy gene called SMN2 has led to the development of several strategies that are designed to elevate SMN levels, and it is clear that SMN2 is an important modifier gene.

Owing to the relatively high correlation of radon and dust over time and the fact that radon is a stronger risk factor than silica, it cannot be ruled out that adjustment for radon including the three effect modifiers may have led to some over adjustment.

Reactions between MDI and CO, performed with –NCO/ OH molar ratios of 8 1 and 4 1, have led to suitable bitumen modifiers.