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Our findings in this study that epigenetic modifiers can upregulate Ezrin expression prompted us to explore the functional consequences of exposure to HDACi and demethylation agents on metastasis.
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We can conclude that hyperosmolarity can upregulate the SPAK expression.
Several growth factors can upregulate AFC.
Runx2 can upregulate miR-1192, which enhances Runx2-induced osteogenic differentiation.
For example, hemin can upregulate Hmox-1 (independently of NO).
Downregulation of cadherins in turn can upregulate Ep-CAM expression.
Moreover, E7 can upregulate the DNA methyltransferase activity of Dnmt1.
In addition, mTOR pathway can upregulate glycolysis in HCC [ 60].
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Of note, multiple reports indicate that inhibitors of epigenetic modifiers can require treatments for several days before observation of significant cellular effects42,43,44.
Disease modifiers can be included if known.
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