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These data indicate that these modifiers can modulate both Ataxin-3 pathogenic protein-based toxicity and CAG-repeat RNA-based toxicity, highlighting the overlap between RNA-based and polyQ protein-based toxicity mechanisms.
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Finally, these results show that rasl11b is a negative modifier that can modulate mesendoderm formation in Zoep mutant.
We also discuss the off-target effects that epigenetic modifiers may have, notably the effects that histone modifiers have on non-histone proteins that can modulate protein expression and activity, as well as the role of hypoxia in epigenetic regulation.
Recently, it has been established that the contribution of genetic modifiers is also of importance for the outcome of a phenotype, since they can modulate the severity of the affected phenotype and the phenotypic characteristics without having a clear effect on the normal situation (Nadeau 2001; Nadeau and Topol 2006).
Modifier: this refers to any drug or drug-like compound or laboratory method that can modulate the biological function of a molecule of interest so to interfere with the efficacy of a therapeutic agent.
Therefore, it seems that this elegant yeast-based method constitutes a valuable tool for investigating gene interaction networks that can modulate cystic fibrosis disease severity, and further enable the identification of so-called modifier genes.
If the liberals can modulate this, they have a fantastic opportunity.
This protein can modulate the activities of FBPase and SBPase42.
"We can't take away pain altogether, but we can modulate it," he said.
Endogenous NO can modulate the development of acute tissue injury.
Furthermore, ionic compounds can modulate enzyme activity.
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