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We examined the effect modifiers at the individual and community levels simultaneously.
Our sensitivity analyses of confounding by seasonal interactions and dichotomizing modifiers at the 75th percentile showed similar results (see Supplemental Material, Tables S1 S3).
For example, lncRNAs can recruit repressive (e.g., PRC2) and activating (e.g., the Trithorax group) chromatin modifiers at the DNA level much like molecular scaffolds, leading to regulation of target gene expression [26 29].
The findings from this study have some public health implications for policymakers and the scientific community by providing evidence of the temperature mortality relationship in China and related effect modifiers at the individual and community levels.
We performed additional sensitivity analyses dichotomizing modifiers at the 75th percentile and using multinomial logistic regression to look at categories of certain modifiers (e.g., race/ethnicity), as well as stratified analyses to examine certain modifiers within strata of another.
In the most extensive study of integration sites in silent and productive sites in primary T cells in five different models of latency [ 66], the epigenetic modifiers at the site of HIV integration even when in an actively transcribed gene had only a modest effect in determining the level of expression, and no consistent features could be demonstrated across the different models.
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Such observations are in keeping with many previous studies regarding the localization of chromatin modifiers at these elements and suggest further testable hypotheses regarding the combinatorial enrichment of potential chromatin modifiers at these regions, which could lead to a better understanding of the mechanism of functioning of enhancers, promoters, and genes.
Four factors were studied: the duration of the initial isocratic step, the percentage of organic modifier at the beginning of the gradient, the percentage of organic modifier at the end of the gradient and the gradient time.
In this study, a new bifunctional electrocatalyst was introduced and used as a modifier at the surface of GC electrode.
Our findings endorse the classification of SETD2 as a tumor suppressor and place inactivating mutations in this histone modifier at the peak of a harmful cascade of events that may ultimately drive malignant cell transformation and tumor development.
Binding of transcription factors and chromatin modifiers at these sites allows appropriate gene expression [ 1].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com