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Extensive connections of O-GlcNAcylation with chromatin modifiers are detected in cells.
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Overall, in 64.6% of the cases, the correct modifier is detected at the top rank.
In a recent genome-wide association study of bone mineral density a significant modifier locus was detected near the SOST gene at 17q21, which encodes sclerostin.
Although the Pitx1 locus explained similar proportions of the variance in these traits in Northern European ninespine sticklebacks as observed in threespine sticklebacks (Shapiro et al. 2004), no significant modifier loci were detected in our study.
Modifiers might have been detected if the number of matching alr loci within the ARC differed between test and out-crossed animals.
Thus, important modifiers might not have been detected by our functional screen design.
No statistically significant interactions between our statistically significant SNPs and potential effect modifiers (age, sex, and BMI) were detected (data not shown).
For additive interaction, variables were considered as potential modifiers if departure from additivity was detected by the interaction contrast ratio (ICR) [ 20, 21].
Modifiers of allelic effects can be detected through alterations in the expected ratios of progeny classes (Zhang et al. 2011), although most quantitative genetics and association experiments have little power to detect such interactions (Carlborg et al. 2003; Cordell 2009).
Additional markers located throughout the genome were therefore tested, and loose linkage of a putative modifier locus to marker NGA139 was detected on chromosome 5 (Table S4).
Higher biocidal activity (up to 99% reduction) was detected when these modifiers were used mutually in coatings materials.
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