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In the subgroup, each effect modifier was excluded from its multivariate model.
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Interestingly, a statistically significant reduction in the ARR and disability progression was also observed when comparing the ARR of the PLP10 patients in the 24-month period prior to the study with the ARR of the 24 months on-study; the observed differences became larger when the patients who received natalizumab (currently the most potent disease modifier) were excluded.
Patients who had previously received treatment with monoclonal antibodies, vaccines or biological response modifiers were excluded.
was excluded.
16 Children with acute asthma, an FEV1<50% 17 and with treatment during the preceding 2 months with ICS, cromones, leukotriene modifiers or long-acting β2-agonists were excluded.
For the meta-analysis of each effect modifier, cities with < 10 observations in a cell were excluded.
In addition, it cannot be excluded that this genotype-phenotype discordance is due to unidentified modifier genes, relevant for the development of pancreatitis.
Patients with severe AD or any other cause of dementia were excluded, as were those receiving cognitive enhancers or disease modifiers other than donepezil, galantamine, rivastigmine, or memantine.
Further, all non-Caucasians (n = 12) were excluded from the analysis because previous studies have shown that race is an important confounder or effect modifier in investigations of polymorphisms and disease.
Seven tests were excluded.
Cesarean deliveries were excluded.
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