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Lastly, failure of Drosophila to confirm modifier status for several of these regions may reflect limitations of using flies to explore GWAS.
While their preliminary data indicate that there is no single common modifier responsible for the variation in tumor burden, genotyping in an additional cohort of extreme subjects to confirm or refute its modifier status is ongoing.
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Potential effect modifiers: Socioeconomic status and child gender were considered to be potential effect modifiers on the basis of previous studies [ 12, 15, 16, 18].
Neither of the other hypothesized effect modifiers (employment status, marital status) was significant.
In addition, we did pre-planned subgroup analyses for the potential effect modifiers baseline status of frailty and mastery.
Should I level up my stamina, knowing that I've got the "sick" status modifier from here on out?
Another potential effect modifier is HIV status.
The most commonly reported potential effect modifier was educational status.
Multivariate models were created to assess the independent primary modifier of KPC status on mortality and length of stay post-infection for survivors.
Associations were evaluated in multiple linear regression analysis including information on the possible confounders or effect modifiers: weight, menopausal status, use of hormone replacement therapy, age at menarche, alcohol consumption, smoking history, and physical activity.
DNA was from breast cancer patients obtained for analysis of their BRCA status and modifier genes (see Table 1 for specific mutations).
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