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Much epidemiologic and case-controlled evidence suggests that diet may be a modifier of prostate cancer risk.
Thus, the hTERT-VNTR2-2nd locus may function as a modifier of prostate cancer risk by affecting gene expression.
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The purpose of this study was to evaluate the role of osteoprotegerin gene (OPG) polymorphisms as genetic modifiers in the etiology of prostate cancer (PCa) and disease progression.
We were unable to examine the association in subgroups defined by disease stage, the trial vitamin supplementation, vitamin D status, or other potential effect modifiers because of the small number of prostate cancer cases with red hair.
Although this sample of tumours is small, these data suggest individual PCa patients have heterogeneous patterns of PTPRR expression relative to other potential modifier genes, and might contribute to the known heterogeneity of prostate tumours.
Swedish study has identified rs2987983 in the promoter region of ESR2, which was not included in our study, as a potential effect modifier in the relationship between the intake of phytoestrogen and the risk of prostate cancer [34].
One of the distinct characteristics of prostate cancer is overexpression of the small ubiquitin-like modifier (SUMO -specific proteaSUMO -specificand the uproteaseion of SENP1 contributes to the mandgnantherogression and cell proliferation of PCa.
Given the potential to reverse aberrant epigenetic modifications, and the promising results that have been reported for some inhibitors of epigenetic modifiers in prostate cancer animal models and clinical trials, further investigation of the mechanisms of action of these agents on prostate cancer cells is warranted.
This enabled us to examine the risk of prostate cancer according to narrow height categories across numerous potentially important effect modifiers.
A potential effect modifier of the association between vitamin D and prostate cancer risk is calcium.
(Papp died of prostate cancer in 1991).
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