Sentence examples for modifier of age from inspiring English sources

The SNCA gene has recently been identified as a major modifier of age of PD onset.

It has recently been shown that the SNCA gene is a major modifier of age of PD onset [ 23].

Using family-based tests and incorporating age of onset information, they identified a SNP on chromosome 14q31 that, like the APOE variants, appears to be a modifier of age of onset, while other SNPs with weaker signals were also reported.

The results of our study do not provide strong evidence for PPARGC1A SNP rs7665116, and therefore, for PGC-1α, as a modifier of age at onset of HD motor symptoms.

Two recent association mapping studies in Parkinson disease (PD) reported three candidate genes for the PARK10 locus: EIF2B3 as a modifier of age-at-onset of PD (min P= 0.0004) and HIVEP3 as a PD risk gene (P < or = 0.006) (Oliveira et al. 2005); and LOC200008 (CDCP2) identified by the whole genome association (WGA) study of PD of Maraganore et al. (2005).

However, recent study on a large cohort of DM1 individuals showed that the estimated progenitor allele length was the major modifier of age-at-onset of the disease, accounting for 64% of the variation, without the threshold above which repeat length did not contribute toward age-at-onset [ 88].

Evidence that heritable factors in humans can alter the course of HD came initially from the HD-MAPS (Modifiers of Age at onset in Pairs of Sibs) study, in which sibling pairs and small families from an international collaborative group were investigated for age at motor onset [ 11].

In model organisms, alterations to these conserved genetic modifiers of aging can impact both survival (lifespan) and health span, the percentage of life spent free from significant pathology.

Given that we found no evidence of an effect modifier for age, the clinical interpretation should be that increasing age is associated with less discordance between radiographic and orthopedic examination findings.

As a modifier of radiation risk, age at first parity seems more important than menarche and age at menopause in the etiology of breast cancer.

Sex (n = 31 males, n = 43 females) was a significant modifier of the effect of age on methylation in CpG -186.