Sentence examples for modifier model from inspiring English sources

Estimation of the average increased risk associated with PALB2 mutations has been performed previously using an indirect method by presuming a polygenic modifier model.

Representation of the substrate inhibition model, which is based on the 2-site modifier model originally proposed by Schmidtke et al. (2000).

We have previously proposed that there are potentially two plausible genetic models of AD with D+H [ 1]: first, a heterogeneity model in which alleles predispose or are protective against the development of AD pathology and subsequent psychosis and, second, a disease-modifier model in which alleles increase the risk of psychosis but only in the presence of AD.

To examine the influence of area variables on birth outcomes across social markers potentially serving as effect modifiers, models were re-run after stratifying data according to maternal birthplace (foreign- versus Canadian-born) and education (high school diploma or less versus some post-secondary or more).

As in the case of cinchonidine, the most used modifier, the model predicts enantiomeric excess in nearly quantitative agreement with experiment.

This chapter focuses on the applications in fuzzy rule-based systems along with the understanding of the construction of two binary ordering-based modifiers that model a concept of fuzzy between, both in an inclusive and a non-inclusive setting.

In this domain, the retention as a function of the proportion of organic modifier is modeled using a two-stage re-calibration process departing from isocratic retention data and then, from gradient elutions.

Figure  4f suggests some genes were not identified as modifiers in HD models with a polyQ length of 40 (which is above the canonical threshold of 35), but were then identified as modifier in models with a polyQ length of 60.

Confounding, BPA exposure misclassification, differences in distributions of effect measure modifiers, incorrect model specification, or residual sources of selection bias may explain the discrepancies across epidemiological studies (Howe et al. 2011).

Although there is an inherent level of variability in gene expression, this method has proved powerful for the study of disease modifiers in models of polyglutamine disease [14] and motor neuron disease [16 19] and in the evaluation of therapeutic strategies [15].

Results from the analysis of genetic modifiers in other model organism as well as the comparison of modifiers in all three model organisms are available in Additional file 1. i) NeuroGeM can be used to identify biological processes that are enriched within genetic modifiers in a specific disease or in groups of diseases.