Sentence examples for modifier loci and from inspiring English sources

We ran two types of simulations: those with populations homogeneous at the modifier loci; and those of modifier allele invasions.

The fact that they are there, however, is clear from the existence of modifier loci and other effects in relation to both complex and Mendelian disorders.

The extreme phenotypic variability in RDDs can be attributed to allelic heterogeneity, modifier loci, and epigenetic and environmental factors, or a combination of these.

These results illustrate the power of CAPE in identifying novel modifier loci and interactions in a complex neurological disease, towards a more comprehensive view of its underlying genetic architecture.

Ongoing GWAS in BRCA1 and BRCA2 mutation carriers and in the general population are likely to identify further modifier loci and taken together, they may lead to more accurate risk predictions in mutation carriers with implications for clinical management, and to a better understanding of the biology of tumour development in mutation carriers.

Within the employed haploid model, individuals are characterized by their sex, their genotype at the modifier locus, and their cytoplasmic infection status with Wolbachia.

Segregation is Mendelian and recombination between the modifier locus and the fitness loci is free (as if they are located on separate chromosomes).

More importantly, these models presumably have been interpreted as though the mutational cause of the alleles in the modifier locus and in the other loci is accidental.

Because of its localization within the Mom-1 (Min modifier) locus, and its promotion of tumors in APCMin mice, it had first been suggested that PLA2G2A may represent a tumor suppressor gene involved in familial forms of CRC [ 44].

One would expect that genes for proteins interacting either directly with ATP7B or influencing it indirectly might fit the role of modifier locus and genes of copper homeostasis pathway could have such potential.

Herein, we used an interspecific backcross between the Mus musculus strain A/J and the Mus spretus strain SPRET/EiJ to map 6 additional CRC modifier loci Scc16-211) and 2 suggestive loci.