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This established interaction strongly supports findings here showing that sgl is a strong genetic modifier in our CG disease model.
Malaria was a potential effect modifier in our study, and we did not examine placental histology to assess this in detail.
A limitation is that we were not able to evaluate pneumonia severity as a potential confounder or effect modifier in our multivariable analyses.
A history of 5-α reductase use in the six months before starting α antagonist treatment was a significant effect modifier in our study (P=0.02) and trended towards a decreased risk of falls (odds ratio 0.88 (0.70 to 1.10)).
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In (3.11), very functions as a predicate modifier, in particular a subsective modifier, since the set of things that are very(P) is a subset of the things that are P. Do we need such modifiers in our logical forms?
The rather compelling case for intensional predicate modifiers in our semantic vocabulary reinforces the case made above (on the basis on extensional examples) for allowing predicate modification.
Importantly, we did not observe selective pressure against homozygous mutant combinations in any of the crosses we performed (not shown), strongly suggesting that potentially lethal phenotypes are not repressed by the presence of genetic modifiers in our genetic backgrounds.
The reappearance of escapers in the outcrossed stock was consistent with the accumulation of genetic modifiers in our original stock and suggested that lamP has dominant effects on fitness (see Discussion).
Although the c-Myc penetrance-modifier in our study remains unknown, methylation of the MMTV-LTR promotional element, silencing of linked transgene expression, and abrogation of transgene-dependent tumorigenesis has been described previously (Mangues et al, 1995; Betzl et al, 1996; Zhou et al, 2001).
We did not prespecify effect modifiers in our analysis.
In addition, we have excluded the existence of unlinked modifiers in our mouse models by intercross experiments.
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