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As a result, we can approximate the fitness benefits enjoyed by a new mutation that we introduce after a previous male-specific modifier has reached fixation (see eq.38 of Appendix S1).
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He has reached its summit.
Fayyad has reached the limit.
Globalisation has reached the Himalayas.
It has reached its limit.
AMR has reached that point.
Crime has reached new heights.
Doing so, would not only reduce the capacity for directly sexually antagonistic trajectories of mito-nuclear coevolution, but increase the capacity for nuclear modifier alleles to evolve that mitigate the effects of male-harming mtDNA mutations that have reached fixation in populations.
Few have reached five.
Alex had reached him.
You have reached Moviefone".
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