Sentence examples for modifier genes were from inspiring English sources

Several modifier genes were reported in carriers of BRCA1/2 mutation.

Phospho-tau levels from protein extracts of flies expressing gl-tau in trans to modifier genes were analyzed by immunoblot (Fig.  6).

In an independent microarray data set we found that these chromatin modifier genes were also able to discriminate samples according to tissue type, although the degree of discrimination was much smaller.

Finally, to ascertain whether the EY element insertion was a GOF or LOF allele, the 14 modifier genes were crossed to the original gl-tau fly without GMR-GAL4.

Individual worm orthologues of yeast and fly modifier genes were identified by searching the Princeton Protein Orthology Database (P-POD version 4) (http://ortholog.princeton.edu/findorthofamily.html) [ 26] and use of OrthoMCL [ 67] to determine the appropriate orthologues.

The expression levels of the 12 chromatin modifier genes were analysed using QRT-PCR in 47 cancer cell lines (ovarian, breast, colorectal) and 178 primary samples: 20 colorectal tumour/normal pairs, 12 renal tumour/normal pairs, 26 breast tumours, 5 normal breast tissue samples, 45 ovarian tumours, 15 glioblastomas, 17 bladder tumours, and 6 normal bladder tissue samples.

Moreover, the admixture of ethnic groups plays an important role in the characterization of modifying effects, as modifier genes are diverse in different ethnicities and their complexity increases in ethnically admixed populations according to the extent of gene flow.

An NGS panel targeting the coding regions of hemoglobin genes and four modifier genes was designed.

Because of the great clinical variability between PXE patients the involvement of modifier genes was recently suggested.

The effects of modifier genes are not carried to the offspring when members of different geographic races are crossed.

Determining modifier genes is extremely important for understanding differences in both normal and disease phenotypes, and for designing potential therapeutic avenues for disease.