Sentence examples for modifier genes of from inspiring English sources
Recent functional studies of modifier genes of hearing-loss loci have begun to refine our understanding of hearing processes and will guide the rational design of medical therapies for hearing loss.
This model allows potential modifier genes of the DeltaF508 CFTR allele to be uncovered.
This phenomenon has been previously addressed by studying modifier genes of cotyledon number in Antirrhinum majus (e. g. [ 52]).
Collectively, we have identified a single polymorphic locus that affects skin and lung tumorigenesis and identify Igfbp5 and Igfbp2 as candidate modifier genes of lung tumorigenesis.
We have carried out large-scale genetic screens in Drosophila melanogaster, Caenorhabditis elegans, and cells to identify modifier genes of cancer-related pathways and phenotypes.
Nevertheless, our findings provide a firm starting point to unravel modifier genes of NPC proliferation and offer novel insights into the dynamic interplay of regulatory pathways controlling this process.
The hypoactive phenotype observed in Ts1Cje mice is surprising and exemplifies the effect of modifier genes on the expression of a given phenotype.
We also crossed this mouse with a knockout of H19, a postulated imprinted modifier gene of Sdhd tumorigenesis, to evaluate if loss of these genes together would lead to the initiation or enhancement of tumor development.
This study, which provides new insights into the role of SAA1 in the pathophysiology of FMF, represents the first example of deviations from HWE and selection involving the modifier gene of a Mendelian disorder.
Although these data fail to support a hypothesis that SLC26A5 acts as a modifier gene of GJB2-related hearing loss, the sample size is small and investigation of a larger population might be more informative.
The 22 patients carrying known or potential mutations in GJB2 were included in this study specifically to test the hypothesis that SLC26A5 might act as a modifier gene of GJB2-based hearing loss.
